Partner: Nehar Celikkin

Warsaw University of Technology (PL)

Recent publications
1.Paradiso A., Volpi M., Rinoldi C., Celikkin N., Contessi Negrini N., Bilgen M., Dallera G., Pierini F., Costantini M., Święszkowski W., Farè S., In vitro functional models for human liver diseases and drug screening: beyond animal testing, Biomaterials Science, ISSN: 2047-4849, DOI: 10.1039/d1bm01872h, Vol.11, No.9, pp.2988-3015, 2023
2.Celikkin N., Rinoldi C., Costantini M., Trombetta M., Rainer A., Święszkowski W., Naturally derived proteins and glycosaminoglycan scaffolds for tissue engineering applications, Materials Science and Engineering C, ISSN: 0928-4931, DOI: 10.1016/j.msec.2017.04.016, Vol.78, pp.1277-1299, 2017
Abstract:

Tissue engineering (TE) aims to mimic the complex environment where organogenesis takes place using advanced materials to recapitulate the tissue niche. Cells, three-dimensional scaffolds and signaling factors are the three main and essential components of TE. Over the years, materials and processes have become more and more sophisticated, allowing researchers to precisely tailor the final chemical, mechanical, structural and biological features of the designed scaffolds. In this review, we will pose the attention on two specific classes of naturally derived polymers: fibrous proteins and glycosaminoglycans (GAGs). These materials hold great promise for advances in the field of regenerative medicine as i) they generally undergo a fast remodeling in vivo favoring neovascularization and functional cells organization and ii) they elicit a negligible immune reaction preventing severe inflammatory response, both representing critical requirements for a successful integration of engineered scaffolds with the host tissue. We will discuss the recent achievements attained in the field of regenerative medicine by using proteins and GAGs, their merits and disadvantages and the ongoing challenges to move the current concepts to practical clinical application.

Keywords:

Natural polymers, Hydrogel scaffolds, Glycosaminoglycans (GAGs), Fibrous proteins, Regenerative medicine

Affiliations:
Celikkin N.-Warsaw University of Technology (PL)
Rinoldi C.-other affiliation
Costantini M.-Sapienza University of Rome (IT)
Trombetta M.-Università Campus Bio-Medico di Roma (IT)
Rainer A.-Università Campus Bio-Medico di Roma (IT)
Święszkowski W.-other affiliation

List of chapters in recent monographs
1.
625
Costantini M., Testa S., Rinoldi C., Celikkin N., Idaszek J., Colosi C., Gargioli C., Święszkowski W., Barbetta A., Biomaterials Science Series, Biofabrication and 3D Tissue Modeling, rozdział: 3D Tissue Modelling of Skeletal Muscle Tissue, Royal Society of Chemistry, Edited by Dong-Woo Cho, 3, pp.184-215, 2019