| Partner: Kinga Żelechowska-Matysiak |
Recent publications
| 1. | Osial M., Wilczewski S.♦, Szulc J.♦, Nguyen Hai D.♦, Nguyen Thi Kieu O.♦, Skórczewska K.♦, Majkowska-Pilip A.♦, Żelechowska-Matysiak K.♦, Nieciecka D.♦, Pręgowska A., Nguyen Thu P.♦, Tymoszuk A.♦, Kulus D.♦, Giersig M., Nanohydroxyapatite Loaded with 5-Fluorouracil and Calendula officinalis L. Plant Extract Rich in Myo-Inositols for Treatment of Ovarian Cancer Cells, Coatings, ISSN: 2079-6412, DOI: 10.3390/coatings13111944, Vol.13, No.1944, pp.1-21, 2023 Keywords: hydroxyapatite, myo-inositol, 5-fluorouracil, anticancer treatment, SKOV-3, calendula extract, Langmuir trough Affiliations:
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| 2. | Olusegun S.♦, Osial M., Majkowska-Pilip A.♦, Żelechowska-Matysiak K.♦, Nieciecka D.♦, Krajewski M.♦, Pękała M.♦, Krysiński P.♦, Synthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application, CERAMICS INTERNATIONAL, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2023.03.102, pp.1-10, 2023 Abstract: Commendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug delivery application. Based on the characterization, the diffractogram shows that only one phase related to magnetite with a crystallite size of 10 nm was formed. TEM images revealed nanoparticles of spherical shapes of approximately 12 nm. There is no difference in magnetic saturation of the as-received synthesized samples (Fe3O4@Sr and Fe3O4@Gd), while the BET-specific surface area of Fe3O4@Gd is 8 m2 g−1 higher than Fe3O4@Sr. The heat generation in alternating magnetic field (the magnetic hyperthermia) of Fe3O4@Sr functionalized with citric acid and loaded with 5- fluorouracil (Fe3O4@Sr@CA@5-flu) is slower than Fe3O4@Gd@CA@5-flu. The specific absorption rate (SAR) of Fe3O4@Gd@CA@5-flu, 112.0 ± 10.4 W g−1 was found to be higher than that of Fe3O4@Sr@CA@5-flu. The thermogram shows that 11% of the drug was successfully loaded on Fe3O4@Gd@CA@5-flu. The release of the antitumor drug by the synthesized nanoparticle drug carriers for ovarian cancer (SKOV-3 cells) therapy showed that more than 50% of the cancer cell’s viability was reduced after 72 h of incubation. The synthesized nanoparticles demonstrated a promising drug carrier for the treatment of SKOV-3 cells. Affiliations:
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| 3. | Nguyen Phuong T.♦, Wilczewski S.♦, Lewandowski J.♦, Majkowska-Pilip A.♦, Żelechowska-Matysiak K.♦, Nieciecka D.♦, Studziński W.♦, Olusegun Joseph S.♦, Syczewski M.♦, Giersig M., Dinh Thi Mai T.♦, Krysiński P.♦, Osial M., 5-fluorouracil and curcuminoids extract from Curcuma longa L. loaded into nanohydroxyapatite as a drug delivery carrier for SKOV-3 and HepG2 cancer cells treatment, CERAMICS INTERNATIONAL, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2023.05.123, pp.1-13, 2023 Keywords: Drug delivery, Hydroxyapatite, Anticancer, 5-fluorouracil, Curcuminoids, Nanocomposite Affiliations:
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| 4. | Nieciecka D.♦, Celej J.♦, Żuk M.T.♦, Majkowska-Pilip A.♦, Żelechowska-Matysiak K.♦, Lis A.♦, Osial M., Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin, Pharmaceutics, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics13040480, Vol.13, No.4, pp.1-22, 2021 Keywords: SPIONs, doxorubicin, epirubicin, magnetic hyperthermia, cytotoxicity, Langmuir- Blodgett technique Affiliations:
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