Partner: Agnieszka Majkowska-Pilip


Recent publications
1.Osial M., Wilczewski S., Szulc J., Nguyen Hai D., Nguyen Thi Kieu O., Skórczewska K., Majkowska-Pilip A., Żelechowska-Matysiak K., Nieciecka D., Pręgowska A., Nguyen Thu P., Tymoszuk A., Kulus D., Giersig M., Nanohydroxyapatite Loaded with 5-Fluorouracil and Calendula officinalis L. Plant Extract Rich in Myo-Inositols for Treatment of Ovarian Cancer Cells, Coatings, ISSN: 2079-6412, DOI: 10.3390/coatings13111944, Vol.13, No.1944, pp.1-21, 2023
Keywords:

hydroxyapatite, myo-inositol, 5-fluorouracil, anticancer treatment, SKOV-3, calendula extract, Langmuir trough

Affiliations:
Osial M.-IPPT PAN
Wilczewski S.-other affiliation
Szulc J.-other affiliation
Nguyen Hai D.-other affiliation
Nguyen Thi Kieu O.-other affiliation
Skórczewska K.-other affiliation
Majkowska-Pilip A.-other affiliation
Żelechowska-Matysiak K.-other affiliation
Nieciecka D.-other affiliation
Pręgowska A.-IPPT PAN
Nguyen Thu P.-other affiliation
Tymoszuk A.-other affiliation
Kulus D.-other affiliation
Giersig M.-IPPT PAN
2.Olusegun S., Osial M., Majkowska-Pilip A., Żelechowska-Matysiak K., Nieciecka D., Krajewski M., Pękała M., Krysiński P., Synthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application, CERAMICS INTERNATIONAL, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2023.03.102, pp.1-10, 2023
Abstract:

Commendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug delivery application. Based on the characterization, the diffractogram shows that only one phase related to magnetite with a crystallite size of 10 nm was formed. TEM images revealed nanoparticles of spherical shapes of approximately 12 nm. There is no difference in magnetic saturation of the as-received synthesized samples (Fe3O4@Sr and Fe3O4@Gd), while the BET-specific surface area of Fe3O4@Gd is 8 m2 g−1 higher than Fe3O4@Sr. The heat generation in alternating magnetic field (the magnetic hyperthermia) of Fe3O4@Sr functionalized with citric acid and loaded with 5- fluorouracil (Fe3O4@Sr@CA@5-flu) is slower than Fe3O4@Gd@CA@5-flu. The specific absorption rate (SAR) of Fe3O4@Gd@CA@5-flu, 112.0 ± 10.4 W g−1 was found to be higher than that of Fe3O4@Sr@CA@5-flu. The thermogram shows that 11% of the drug was successfully loaded on Fe3O4@Gd@CA@5-flu. The release of the antitumor drug by the synthesized nanoparticle drug carriers for ovarian cancer (SKOV-3 cells) therapy showed that more than 50% of the cancer cell’s viability was reduced after 72 h of incubation. The synthesized nanoparticles demonstrated a promising drug carrier for the treatment of SKOV-3 cells.

Affiliations:
Olusegun S.-other affiliation
Osial M.-IPPT PAN
Majkowska-Pilip A.-other affiliation
Żelechowska-Matysiak K.-other affiliation
Nieciecka D.-other affiliation
Krajewski M.-other affiliation
Pękała M.-other affiliation
Krysiński P.-other affiliation
3.Nguyen Phuong T., Wilczewski S., Lewandowski J., Majkowska-Pilip A., Żelechowska-Matysiak K., Nieciecka D., Studziński W., Olusegun Joseph S., Syczewski M., Giersig M., Dinh Thi Mai T., Krysiński P., Osial M., 5-fluorouracil and curcuminoids extract from Curcuma longa L. loaded into nanohydroxyapatite as a drug delivery carrier for SKOV-3 and HepG2 cancer cells treatment, CERAMICS INTERNATIONAL, ISSN: 0272-8842, DOI: 10.1016/j.ceramint.2023.05.123, pp.1-13, 2023
Keywords:

Drug delivery, Hydroxyapatite, Anticancer, 5-fluorouracil, Curcuminoids, Nanocomposite

Affiliations:
Nguyen Phuong T.-other affiliation
Wilczewski S.-other affiliation
Lewandowski J.-other affiliation
Majkowska-Pilip A.-other affiliation
Żelechowska-Matysiak K.-other affiliation
Nieciecka D.-other affiliation
Studziński W.-other affiliation
Olusegun Joseph S.-other affiliation
Syczewski M.-other affiliation
Giersig M.-IPPT PAN
Dinh Thi Mai T.-other affiliation
Krysiński P.-other affiliation
Osial M.-IPPT PAN
4.Żuk M.T., Gawęda W., Majkowska-Pilip A., Osial M., Wolski M., Bilewicz A., Paweł K., Hybrid radiobioconjugated superparamagnetic iron oxide-based nanoparticles for multimodal cancer therapy, Pharmaceutics, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics13111843, Vol.13, No.11, pp.1-17, 2021
Keywords:

SPION,radio-labeled nanoparticles,anticancer therapy,magnetic hyperthermia,drug delivery,trastuzumab,superparamagnetic nanoparticles

Affiliations:
Żuk M.T.-NanoThea Inc. (PL)
Gawęda W.-other affiliation
Majkowska-Pilip A.-other affiliation
Osial M.-IPPT PAN
Wolski M.-other affiliation
Bilewicz A.-other affiliation
Paweł K.-other affiliation
5.Nieciecka D., Celej J., Żuk M.T., Majkowska-Pilip A., Żelechowska-Matysiak K., Lis A., Osial M., Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin, Pharmaceutics, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics13040480, Vol.13, No.4, pp.1-22, 2021
Keywords:

SPIONs, doxorubicin, epirubicin, magnetic hyperthermia, cytotoxicity, Langmuir- Blodgett technique

Affiliations:
Nieciecka D.-other affiliation
Celej J.-other affiliation
Żuk M.T.-NanoThea Inc. (PL)
Majkowska-Pilip A.-other affiliation
Żelechowska-Matysiak K.-other affiliation
Lis A.-other affiliation
Osial M.-IPPT PAN