Partner: F. Petronella |
Recent publications
1. | Zaccagnini F.♦, De Biase D.♦, Bovieri F.♦, Perotto G.♦, Quagliarini E.♦, Bavasso I.♦, Mangino G.♦, Iuliano M.♦, Calogero A.♦, Romeo G.♦, Pratap Singh D.♦, Pierini F., Caracciolo G.♦, Petronella F.♦, De Sio L.♦, Multifunctional FFP2 Face Mask for White Light Disinfection and Pathogens Detection using Hybrid Nanostructures and Optical Metasurfaces, Small, ISSN: 1613-6810, DOI: 10.1002/smll.202400531, pp.2400531-1-15, 2024 Abstract: A new generation of an FFP2 (Filtering Face Piece of type 2) smart face mask is achieved by integrating broadband hybrid nanomaterials and a self-assembled optical metasurface. The multifunctional FFP2 face mask shows simultaneously white light-assisted on-demand disinfection properties and versatile biosensing capabilities. These properties are achieved by a powerful combination of white light thermoplasmonic responsive hybrid nanomaterials, which provide excellent photo-thermal disinfection properties, and optical metasurface-based colorimetric biosensors, with a very low limit of pathogens detection. The realized system is studied in optical, morphological, spectroscopic, and cell viability assay experiments and environmental monitoring of harmful pathogens, thus highlighting the extraordinary properties in reusability and pathogens detection of the innovative face mask. Affiliations:
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2. | Zakrzewska A., Haghighat Bayan M.A., Nakielski P., Petronella F.♦, De Sio L.♦, Pierini F., Nanotechnology Transition Roadmap toward Multifunctional Stimuli-Responsive Face Masks, ACS Applied Materials and Interfaces, ISSN: 1944-8244, DOI: 10.1021/acsami.2c10335, Vol.14, No.41, pp.46123-46144, 2022 Abstract: In recent times, the use of personal protective equipment, such as face masks or respirators, is becoming more and more critically important because of common pollution; furthermore, face masks have become a necessary element in the global fight against the COVID-19 pandemic. For this reason, the main mission of scientists has become the development of face masks with exceptional properties that will enhance their performance. The versatility of electrospun polymer nanofibers has determined their suitability as a material for constructing “smart” filter media. This paper provides an overview of the research carried out on nanofibrous filters obtained by electrospinning. The progressive development of the next generation of face masks whose unique properties can be activated in response to a specific external stimulus is highlighted. Thanks to additional components incorporated into the fiber structure, filters can, for example, acquire antibacterial or antiviral properties, self-sterilize the structure, and store the energy generated by users. Despite the discovery of several fascinating possibilities, some of them remain unexplored. Stimuli-responsive filters have the potential to become products of large-scale availability and great importance to society as a whole. Keywords:nanostructured face masks, stimuli-responsive nanomaterials, electrospun nanofibers, active filtration, smart filters, COVID-19, antipathogen Affiliations:
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3. | Ziai Y., Petronella F.♦, Rinoldi C., Nakielski P., Zakrzewska A., Kowalewski T.A., Augustyniak W.♦, Li X.♦, Calogero A.♦, Sabała I.♦, Ding B.♦, De Sio L.♦, Pierini F., Chameleon-inspired multifunctional plasmonic nanoplatforms for biosensing applications, NPG Asia Materials, ISSN: 1884-4049, DOI: 10.1038/s41427-022-00365-9, Vol.14, pp.18-1-17, 2022 Abstract: One of the most fascinating areas in the field of smart biopolymers is biomolecule sensing. Accordingly, multifunctional biomimetic, biocompatible, and stimuli-responsive materials based on hydrogels have attracted much interest. Within this framework, the design of nanostructured materials that do not require any external energy source is beneficial for developing a platform for sensing glucose in body fluids. In this article, we report the realization and application of an innovative platform consisting of two outer layers of a nanocomposite plasmonic hydrogel plus one inner layer of electrospun mat fabricated by electrospinning, where the outer layers exploit photoinitiated free radical polymerization, obtaining a compact and stable device. Inspired by the exceptional features of chameleon skin, plasmonic silver nanocubes are embedded into a poly(N-isopropylacrylamide)-based hydrogel network to obtain enhanced thermoresponsive and antibacterial properties. The introduction of an electrospun mat creates a compatible environment for the homogeneous hydrogel coating while imparting excellent mechanical and structural properties to the final system. Chemical, morphological, and optical characterizations were performed to investigate the structure of the layers and the multifunctional platform. The synergetic effect of the nanostructured system’s photothermal responsivity and antibacterial properties was evaluated. The sensing features associated with the optical properties of silver nanocubes revealed that the proposed multifunctional system is a promising candidate for glucose-sensing applications. Affiliations:
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4. | De Sio L.♦, Ding B.♦, Focsan M.♦, Kogermann K.♦, Pascoal-Faria P.♦, Petronella F.♦, Mitchell G.♦, Zussman E.♦, Pierini F., Personalized reusable face masks with smart nano‐assisted destruction of pathogens for COVID‐19: a visionary road, Chemistry - A European Journal, ISSN: 0947-6539, DOI: 10.1002/chem.202004875, Vol.27, pp.1-20, 2021 Abstract: The Coronavirus disease 2019 (COVID‐19) emergency has demonstrated that the utilization of face masks plays a critical role in limiting the outbreaks. Healthcare professionals utilize masks all day long without replacing them very frequently, thus representing a source of cross‐infection for patients and themselves. Nanotechnology is a powerful tool with the capability to produce nanomaterials with unique physicochemical and anti‐pathogen properties. Here, we outline how to realize non‐disposable and highly comfortable respirators with light‐triggered self‐disinfection ability by bridging bioactive nanofiber properties and stimuli‐responsive nanomaterials. The visionary road highlighted in this Concept is based on the possibility to develop a new generation of masks based on multifunctional membranes where the presence of nanoclusters and plasmonic nanoparticles arranged in a hierarchical structure enables the realization of a chemically‐driven and on‐demand anti‐pathogen activities. Multilayer electrospun membranes have the ability to dissipate humidity present within the mask, enhancing the wearability and usability. The photo‐thermal disinfected membrane is the core of these 3D printed and reusable masks with moisture pump capability. Personalized face masks with smart nano‐assisted destruction of pathogens will bring enormous advantages to the entire global community, especially for front‐line personnel, and will open up great opportunities for innovative medical applications. Keywords:face masks, light-responsive nanomaterials, anti-pathogen, electrospinning, digitally personalized Affiliations:
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5. | Rinoldi C., Zargarian S.S., Nakielski P., Li X.♦, Liguori A.♦, Petronella F.♦, Presutti D.♦, Wang Q.♦, Costantini M.♦, De Sio L.♦, Gualandi C.♦, Ding B.♦, Pierini F., Nanotechnology-assisted RNA delivery: from nucleic acid therapeutics to COVID-19 vaccines, Small Methods, ISSN: 2366-9608, DOI: 10.1002/smtd.202100402, Vol.5, No.9, pp.2100402-1-49, 2021 Abstract: In recent years, the main quest of science has been the pioneering of the groundbreaking biomedical strategies needed for achieving a personalized medicine. Ribonucleic acids (RNAs) are outstanding bioactive macromolecules identified as pivotal actors in regulating a wide range of biochemical pathways. The ability to intimately control the cell fate and tissue activities makes RNA-based drugs the most fascinating family of bioactive agents. However, achieving a widespread application of RNA therapeutics in humans is still a challenging feat, due to both the instability of naked RNA and the presence of biological barriers aimed at hindering the entrance of RNA into cells. Recently, material scientists’ enormous efforts have led to the development of various classes of nanostructured carriers customized to overcome these limitations. This work systematically reviews the current advances in developing the next generation of drugs based on nanotechnology-assisted RNA delivery. The features of the most used RNA molecules are presented, together with the development strategies and properties of nanostructured vehicles. Also provided is an in-depth overview of various therapeutic applications of the presented systems, including coronavirus disease vaccines and the newest trends in the field. Lastly, emerging challenges and future perspectives for nanotechnology-mediated RNA therapies are discussed. Affiliations:
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List of chapters in recent monographs
1. 720 | Petronella F.♦, Stoia D.♦, Ziai Y., Zaccagnini F.♦, Scognamiglio V.♦, Maniu D.♦, Rinoldi C., Focsan M.♦, Antonacci A.♦, Pierini F., De Sio L.♦, Novel Optical Materials, rozdział: Chapter 6: Plasmonic-based Biosensors for the Rapid Detection of Harmful Pathogens, World Scientific, 1, pp.155-194, 2023 |
Conference abstracts
1. | Ziai Y., Petronella F.♦, Rinoldi C., Nakielski P., De Sio L.♦, Pierini F., An AgNPs-incorporated hydrogel-based nanocomposite for lysozyme biosensing, NANOMAT2023, 6th International Conference on Functional Nanomaterials and Nanodevices, 2023-08-27/08-30, Warsaw (PL), No.075, pp.109, 2023 Abstract: Lysozyme, an enzyme found in various bodily fluids, holds immense importance as a biomolecule with numerous diagnostic implications. In the realm of ophthalmology, lysozyme detection in tears emerges as a precious tool for identifying and addressing dry and inflamed eyes. To enhance the precision and efficiency of lysozyme detection, Smart materials, such as hydrogels and electrospun nanofibers, have been confirmed to be promising candidates for sensing platforms. Plasmonic nanoparticles, on the other hand, offer enhanced optical properties that allow for localized surface plasmon resonance (LSPR), which has been used alongside these substrates. By integrating these smart materials into biosensing platforms, researchers can achieve rapid, reliable, and non-invasive lysozyme detection from tears.
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