Partner: J. Czwartos

Ostatnie publikacje
1.Czwartos J., Zaszczyńska A., Nowak-Stępniowska A., Fok T., Budner B., Bartnik A., Wachulak P., Kołbuk D., Sajkiewicz P., Fiedorowicz H., The novel approach to physico-chemical modification and cytocompatibility enhancement of fibrous polycaprolactone (PCL) scaffolds using soft X-ray/extreme ultraviolet (SXR/EUV) radiation and low-temperature, SXR/EUV induced, nitrogen and oxygen plasmas, APPLIED SURFACE SCIENCE, ISSN: 0169-4332, DOI: 10.1016/j.apsusc.2022.154779, Vol.606, pp.154779-1-12, 2022


The fundamental aspect of the fabrication of microporous, fibrous biomaterials in form of scaffolds is the optimization of their surface properties to enhance cellular response. In this work, a novel approach to physico-chemical modification and bioactivity enhancement of electrospun fibrous polycaprolactone (PCL) nonwovens using soft X-ray/extreme ultraviolet (SXR/EUV) irradiation and exposure to a low-temperature, SXR/EUV induced, nitrogen and oxygen plasmas is presented for the first time. Chemical alterations and morphology of the fibrous structure of irradiated PCL mats were examined using X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM), respectively. The impact of introduced changes on viability, morphology, and adhesion of L929 mouse fibroblasts was examined. It was found that simultaneous interaction of SXR/EUV radiation and N2 or O2 photoionized plasmas led to strong chemical decomposition of the surface of fibrous PCL mats. Also, mats’ spatial porous structure was not damaged and the fibers were not broken or fused. All modified samples demonstrated cyto-compatible and non-cytotoxic properties. Enhancement of L929 cell adhesion and increased proliferation were also observed.

Słowa kluczowe:

Soft X-ray/extreme ultraviolet (SXR/EUV) radiation, Low-temperature plasma treatment, Electrospun polycaprolactone (PCL) nonwovens, XPS analysis, L929 mouse fibroblasts, Cytocompatibility enhancement

Afiliacje autorów:

Czwartos J.-other affiliation
Zaszczyńska A.-IPPT PAN
Nowak-Stępniowska A.-other affiliation
Fok T.-other affiliation
Budner B.-other affiliation
Bartnik A.-other affiliation
Wachulak P.-other affiliation
Kołbuk D.-IPPT PAN
Sajkiewicz P.-IPPT PAN
Fiedorowicz H.-other affiliation