Partner: Dongkyu Lee

Ostatnie publikacje
1.Achadu Ojodomo J., Nwaji N., Lee D., Lee J., Akinoglu E.M., Giersig M., Park Enoch Y., 3D hierarchically porous magnetic molybdenum trioxide@gold nanospheres as a nanogap-enhanced Raman scattering biosensor for SARS-CoV-2, Nanoscale Advances, ISSN: 2516-0230, DOI: 10.1039/d1na00746g, Vol.4, pp.871-883, 2022


The global pandemic of COVID-19 is an example of how quickly a disease-causing virus can take root and threaten our civilization. Nowadays, ultrasensitive and rapid detection of contagious pathogens is in high demand. Here, we present a novel hierarchically porous 3-dimensional magnetic molybdenum trioxide–polydopamine-gold functionalized nanosphere (3D mag-MoO3–PDA@Au NS) composed of plasmonic, semiconductor, and magnetic nanoparticles as a multifunctional nanosculptured hybrid. Based on the synthesized 3D mag-MoO3–PDA@Au NS, a universal “plug and play” biosensor for pathogens is proposed. Specifically, a magnetically-induced nanogap-enhanced Raman scattering (MINERS) detection platform was developed using the 3D nanostructure. Through a magnetic actuation process, the MINERS system overcomes Raman signal stability and reproducibility challenges for the ultrasensitive detection of SARS-CoV-2 spike protein over a wide dynamic range up to a detection limit of 10−15 g mL−1. The proposed MINERS platform will facilitate the broader use of Raman spectroscopy as a powerful analytical detection tool in diverse fields.

Afiliacje autorów:

Achadu Ojodomo J.-other affiliation
Nwaji N.-other affiliation
Lee D.-other affiliation
Lee J.-Lexington High School (US)
Akinoglu E.M.-University of Melbourne (AU)
Giersig M.-IPPT PAN
Park Enoch Y.-other affiliation