Partner: A. Bandzerewicz

Politechnika Warszawska (PL)

Ostatnie publikacje
1.Miętus M., Kolankowski K., Gołofit T., Denis P., Bandzerewicz A., Spychalski M., Mąkosa-Szczygieł M., Pilarek M., Wierzchowski K., Gadomska-Gajadhur A., From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications, Gels, ISSN: 2310-2861, DOI: 10.3390/gels9100788, Vol.9, No.788, pp.1-19, 2023

Streszczenie:

Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens’ surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems.

Słowa kluczowe:

poly(glycerol itaconate), polylactide, electrospinning, tissue engineering, hydrogels

Afiliacje autorów:

Miętus M.-other affiliation
Kolankowski K.-other affiliation
Gołofit T.-other affiliation
Denis P.-IPPT PAN
Bandzerewicz A.-Politechnika Warszawska (PL)
Spychalski M.-other affiliation
Mąkosa-Szczygieł M.-other affiliation
Pilarek M.-other affiliation
Wierzchowski K.-other affiliation
Gadomska-Gajadhur A.-Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)
20p.
2.Wrzecionek M., Bandzerewicz A., Dutkowska E., Dulnik J., Denis P., Gadomska-Gajadhur A., Poly(glycerol citrate)-polylactide nonwovens toward tissue engineering applications, Polymers for Advanced Technologies, ISSN: 1042-7147, DOI: 10.1002/pat.5407, Vol.32, No.10, pp.3955-3966, 2021

Streszczenie:

In 2002, Robert Langer proposed that new polyester for tissue engineering should have good mechanical properties followed by: covalent bonding (as crosslinking) and hydrogen-bonding interactions; and should be elastic like rubber materials due to three-dimensional network structure. Considering these hypotheses, a polyester made of glycerol and citric acid was designed in this work. Poly(glycerol citrate) should be attractive for tissue engineering because both glycerol and citric acid, taking part in natural human metabolic pathways; and due to the reactant's functionality, 3D networks should be produced easily. Moreover, the reagents are cheap, available, and often used in the food and pharmaceutical industries. In this work, poly(glycerol citrate) was synthesized and then used with PLA for creating porous nonwovens by electrospinning. Produced materials were tested for possible application in the field of tissue engineering. The obtained materials have properties similar to collagen fibers, but still, require refinement for medical applications.

Słowa kluczowe:

electrospinning, poly(glycerol citrate), polylactide, tissue engineering

Afiliacje autorów:

Wrzecionek M.-Politechnika Warszawska (PL)
Bandzerewicz A.-Politechnika Warszawska (PL)
Dutkowska E.-Politechnika Warszawska (PL)
Dulnik J.-IPPT PAN
Denis P.-IPPT PAN
Gadomska-Gajadhur A.-Nałęcz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences (PL)
70p.

Abstrakty konferencyjne
1.Kolankowski K., Bandzerewicz A., Wrzecionek M., Dulnik J., Denis P., Gadomska-Gajadhur A., Poly(glycerol citrate) + PLLA nonwovens for possible biomedical applications, PSCM 2023, 7th International Conference on Polymer Science and Composite Materials, 2023-10-05/10-06, Rzym (IT), pp.1, 2023
2.Bandzerewicz A., Wierzchowski K., Denis P., Pilarek M., Gadomska-Gajadhur A., Biodegradable and bioresorbable nonwovens based on poly(1,3-propanediol citrate) for ex-vivo cell culturing, PSCM 2023, 7th International Conference on Polymer Science and Composite Materials, 2023-10-05/10-06, Rzym (IT), pp.1, 2023
3.Howis J., Bandzerewicz A., Denis P., Ruśkowski P., Gadomska-Gajadhur A., Potencjał włóknotwórczy poli(cytrynianu 1,2-etanodiolu), XVI Letnia Szkoła Membranowa „Membrany i procesy membranowe w teorii i praktyce”, 2022-07-20/07-22, Szczecin (PL), pp.1, 2022
4.Bandzerewicz A., Wrzecionek M., Denis P., Dulnik J., Wierzchowski K., Gadomska-Gajadhur A., Poliestry na bazie kwasu cytrynowego do otrzymywania nanowłóknin metodą elektroprzędzenia, XVI Letnia Szkoła Membranowa „Membrany i procesy membranowe w teorii i praktyce”, 2022-07-20/07-22, Szczecin (PL), pp.1, 2022
5.Bandzerewicz A., Dulnik J., Denis P., Gadomska-Gajadhur A., Poli(cytrynian gliceryny) do zastosowań biomedycznych, MODPOL21, XXV Konferencja Naukowa „Modyfikacja Polimerów” , 2021-09-06/09-09, Szklarska Poręba (PL), pp.23, 2021