Partner: Yang Si

Donghua University (CN)

Recent publications
1.Wang L., Lv H., Liu L., Zhang Q., Nakielski P., Si Y., Cao J., Li X., Pierini F., Yu J., Ding B., Electrospun nanofiber-reinforced three-dimensional chitosan matrices: architectural, mechanical and biological properties, JOURNAL OF COLLOID AND INTERFACE SCIENCE, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2020.01.016, Vol.565, pp.416-425, 2020
Abstract:

The poor intrinsic mechanical properties of chitosan hydrogels have greatly hindered their practical applications. Inspired by nature, we proposed a strategy to enhance the mechanical properties of chitosan hydrogels by construction of a nanofibrous and cellular architecture in the hydrogel without toxic chemical crosslinking. To this end, electrospun nanofibers including cellulose acetate, polyacrylonitrile, and SiO2 nanofibers were introduced into chitosan hydrogels by homogenous dispersion and lyophilization. With the addition of 30% cellulose acetate nanofibers, the cellular structure could be maintained even in water without crosslinking, and integration of 60% of the nanofibers could guarantee the free-standing structure of the chitosan hydrogel with a low solid content of 1%. Moreover, the SiO2 nanofiber-reinforced chitosan (SiO2 NF/CS) three-dimensional (3D) matrices exhibit complete shape recovery from 80% compressive strain and excellent injectability. The cellular architecture and nanofibrous structure in the SiO2 NF/CS matrices are beneficial for human mesenchymal stem cell adhesion and stretching. Furthermore, the SiO2 NF/CS matrices can also act as powerful vehicles for drug delivery. As an example, bone morphogenetic protein 2 could be immobilized on SiO2 NF/CS matrices to induce osteogenic differentiation. Together, the electrospun nanofiber-reinforced 3D chitosan matrices exhibited improved mechanical properties and enhanced biofunctionality, showing great potential in tissue engineering.

Keywords:

chitosan hydrogel, electrospun nanofiber, mechanical property, nanofibrous matrix, tissue engineering

Affiliations:
Wang L.-Imperial College London (GB)
Lv H.-Medical College of Soochow University (CN)
Liu L.-Donghua University (CN)
Zhang Q.-Medical College of Soochow University (CN)
Nakielski P.-IPPT PAN
Si Y.-Donghua University (CN)
Cao J.-other affiliation
Li X.-Donghua University (CN)
Pierini F.-IPPT PAN
Yu J.-Donghua University (CN)
Ding B.-Donghua University (CN)

Patents
Filing No./Date
Filing Publication
Autor(s)
Title
Protection Area, Applicant Name
Patent Number
Date of Grant
pdf
435749
2020-10-21
BUP 17/2022
2022-04-25
Pierini F., Nakielski P., Rinoldi C., Pawłowska S., Ding B., Li X., Si Y.
Nanoplatforma dostarczania leków na żądanie, sposób jej wytwarzania oraz zastosowanie
PL, Instytut Podstawowych Problemów Techniki PAN
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