Partner: M.P. Mienkina


Recent publications
1.Mienkina M.P., Postema M., Hansen C., Schmitz G., Modelling ultrasonic backscattering of an SPIO-MRI contrast agent, Biomedical Engineering-Biomedizinische Technik, ISSN: 1862-278X, Vol.50, No.S1, Supplement, pp.750-751, 2005
Abstract:

The ultrasonic backscatter coefficient (BSC) of superparamagnetic iron oxide (SPIO) nanoparticles, which are used as a liver MRI contrast agent, was simulated using a Yagi backscattering model. The BSC of SPIO cores that are aggregated in the lysosomes of Kupffer cells is significantly higher (85 dB) than the BSC of non- aggregated SPIO cores. Considering in vivo concentrations, the aggregated SPIO does not elevate the BSC of the liver markedly (9x10-6 dB). Thus, the reported visibility of SPIO in clinical ultrasound cannot be explained by classical scattering theory. Other non-linear effects need to be taken into account.

Affiliations:
Mienkina M.P.-other affiliation
Postema M.-other affiliation
Hansen C.-CERN (CH)
Schmitz G.-other affiliation

List of chapters in recent monographs
1.
463
Hiltawsky K.M., Haisch C., Mienkina M.P., Postema M., Schmitz G., Health Academy, Molecular imaging: Innovationen und Visionen in der medizinischen Bildgebung, rozdział: Optoakustik in der medizinischen Bildgebung, pp.159-175, 2006