| Partner: K. Reczyńska |
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Recent publications
| 1. | Jeznach O.♦, Gajc M.♦, Korzeb K.♦, Kłos A.♦, Orliński K.♦, Stępień R.♦, Krok-Borkowicz M.♦, Rumian Ł.♦, Pietryga K.♦, Reczyńska K.♦, Pamuła E.♦, Pawlak D.A.♦, New calcium-free Na2O-Al2O3-P2O5 bioactive glasses with potential applications in bone tissue engineering, Journal of the American Ceramic Society, ISSN: 0002-7820, DOI: 10.1111/jace.15216, Vol.101, No.2, pp.602-611, 2018 Abstract: Sodium aluminophosphate glasses were evaluated for their bone repair ability. The glasses belonging to the system 45Na2O–xAl2O3-(55-x)P2O5, with x = (3, 5, 7, 10 mol%) were prepared by a melt-quenching method. We assessed the effect of Al2O3 content on the properties of Na2O–Al2O3–P2O5 (NAP) glasses, which were characterized by density measurements, DSC analyses, solubility, bioactivity in simulated body fluid and cytocompatibility with MG-63 cells. To the best of our knowledge, this is the first investigation of calcium-free Na2O–Al2O3–P2O5 system glasses as bioactive materials for bone tissue engineering. Keywords:alumina, bioactive glass, bone tissue engineering, calcium-free bioactive glass, phosphate glass, sodium aluminophosphate glass Affiliations:
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| 2. | Jeznach O.♦, Gajc M.♦, Kłos A.♦, Orliński K.♦, Pawlak D.A.♦, Krok-Borkowicz M.♦, Rumian Ł.♦, Pietryga K.♦, Reczyńska K.♦, Pamuła E.♦, The effect of titanium dioxide addition on physical and biological properties of Na2O-B2O3-P2O5 and CaO-Na2O-P2O5 glasses, ENGINEERING OF BIOMATERIALS / INŻYNIERIA BIOMATERIAŁÓW, ISSN: 1429-7248, Vol.19, No.134, pp.2-7, 2016 Abstract: Two types of phosphate glasses 50Na2O-20B2O3-30P2O5 (NBP) and 30CaO-20Na2O-50P2O5 (CNP) with different content of TiO2 (0, 3 and 5 mol%) have been prepared by melt-quenching process. TiO2 was added to increase glass network stability. Physical properties of glasses were investigated by density measurements, differential scanning calorimetry and degradation in phosphate buffered saline (PBS). Biological performance of glasses in a direct contact with osteoblast-like MG-63 cells was analysed with the use of resazurin test and live-dead staining. The results show that TiO2 addition increased density, glass transition temperature (Tg) and melting temperature (Tm) of both types of glasses. In the case of NBP glasses presence of TiO2 resulted in their fast degradation in PBS and acidification of cell culture medium. As a consequence such glasses did not support cell adhesion and growth, but they can be considered for e.g. drug delivery systems. On the other hand addition of TiO2 to CNP glasses resulted in enhanced cell adhesion and viability. Particularly positive results were found for CNP glass containing 5% TiO2, so it can be a good candidate as a scaffold material for bone tissue engineering. Keywords:phosphate glasses, bioactive glasses, titanium dioxide, tissue engineering Affiliations:
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