| Partner: M Ankers John |
Ostatnie publikacje
| 1. | Ankers John M.♦, Awais R.♦, Jones Nicholas A.♦, Boyd J.♦, Ryan S.♦, Adamson Antony D.♦, Harper Claire V.V.♦, Bridge L.♦, Spiller David G.♦, Jackson Dean A.♦, Paszek P.♦, Sée V.♦, White Michael R.R.♦, Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation, eLife, ISSN: 2050-084X, DOI: 10.7554/eLife.10473, Vol.5, pp.e10473-1-35, 2016 Streszczenie: Dynamic cellular systems reprogram gene expression to ensure appropriate cellular fate responses to specific extracellular cues. Here we demonstrate that the dynamics of Nuclear Factor kappa B (NF-κB) signalling and the cell cycle are prioritised differently depending on the timing of an inflammatory signal. Using iterative experimental and computational analyses, we show physical and functional interactions between NF-κB and the E2 Factor 1 (E2F-1) and E2 Factor 4 (E2F-4) cell cycle regulators. These interactions modulate the NF-κB response. In S-phase, the NF-κB response was delayed or repressed, while cell cycle progression was unimpeded. By contrast, activation of NF-κB at the G1/S boundary resulted in a longer cell cycle and more synchronous initial NF-κB responses between cells. These data identify new mechanisms by which the cellular response to stress is differentially controlled at different stages of the cell cycle. Afiliacje autorów:
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