| Partner: M. Wrobel |
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Ostatnie publikacje
| 1. | Dobkowska-Chudon W.♦, Wrobel M.♦, Karłowicz P.♦, Dabrowski A.♦, Krupienicz A.♦, Targowski T.♦, Nowicki A., Olszewski R., Detecting cerebrovascular changes in the brain caused by hypertension in atrial fibrillation group using acoustocerebrography, PLOS ONE, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0199999, Vol.13, No.7, pp.1-10, 2018 Streszczenie: Acoustocerebrography is a novel, non-invasive, transcranial ultrasonic diagnostic method based on the transmission of multispectral ultrasound signals propagating through the brain tissue. Dedicated signal processing enables the estimation of absorption coefficient, frequency-dependent attenuation, speed of sound and tissue elasticity. Hypertension and atrial fibrillation are well known factors correlated with white matter lesions, intracerebral hemorrhage and cryptogenic stroke numbers. The aim of this study was to compare the acoustocerebrography signal in the brains of asymptomatic atrial fibrillation patients with and without hypertension. The study included 97 asymptomatic patients (40 female and 57 male, age 66.26 +/- 6.54 years) who were clinically monitored for atrial fibrillation. The patients were divided into two groups: group I (patients with hypertension) n = 75, and group II (patients without hypertension) n = 22. Phase and amplitude of all spectral components for the received signals from the brain path were extracted and compared to the phase and amplitude of the transmitted pulse. Next, the time of flight and the attenuation of each frequency component were calculated. Additionally, a fast Fourier transformation was performed and its features were extracted. After introducing a machine learning technique, the ROC plot of differentiations between group I and group II with an AUC of 0.958 (sensitivity 0.99 and specificity 0.968) was obtained. It can be assumed that the significant difference in the acoustocerebrography signals in patients with hypertension is due to changes in the brain tissue, and it allows for the differentiating of high-risk patients with asymptomatic atrial fibrillation and hypertension. Słowa kluczowe: changes in the brain, hypertension in atrial, acoustocerebrography Afiliacje autorów:
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Abstrakty konferencyjne
| 1. | Olszewski R., Dobkowska-Chudon W.♦, Wrobel M.♦, Karlowicz P.♦, Dabrowski A.♦, Krupienicz A.♦, Targowski T.♦, Nowicki A., Is Acoustocerebrography a new noninvasive method for early detection of the brain changes in patients with hypertension?, ESC Congress 2017, European Society of Cardiology Congress 2017, 26-30 August, Barcelona, Spain, 2017-08-26/08-30, Barcelona (ES), DOI: 10.1093/eurheartj/ehx501.P190, Vol.38, No.suppl_1, pp.36, 2017 Streszczenie: Background: Hypertension (HT) is the leading cause of global disease burden and overall health loss. The brain is one of the main target organs affected by HT. HT is a potentially modifiable risk factor that leads to the formation of large vessel macroangiopathy, small vessel disease, microangiopathy, and microhemorrhages. Early detection of the brain changes (BC) gives a chance to receive appropriate treatment and protection from irreversible damage. Acoustocerebrography (ACG) is a set of techniques to capture the states of human brain tissue, and its changes on its molecular and cellular level. It is based on noninvasive measurements of various parameters obtained by analyzing an ultrasound pulse emitted across the human's skull. The main idea of this method relies in the relation between the tissue density, bulk modulus, and speed of propagation, for ultrasound waves in this medium. In our previous studies we showed that ACG is an effective method for detecting white matter lesions compared to the Magnetic Resonance Imaging. Additionally we showed that ACG allows to obtain a differentiated signal originates from atrial fibrillation (AF) patients and high-risk patients wit AF and HT. Afiliacje autorów:
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