| Partner: J. Grimbergen |
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Ostatnie publikacje
| 1. | Piechocka I.K., Kurniawan N.A.♦, Grimbergen J.♦, Koopman J.♦, Koenderink G.H.♦, Recombinant fibrinogen reveals the differential roles of α- and γ-chain cross-linking and molecular heterogeneity in fibrin clot strain-stiffening, Journal of Thrombosis and Haemostasis, ISSN: 1538-7933, DOI: 10.1111/jth.13650, Vol.15, No.5, pp.938-949, 2017 Streszczenie: Essentials Fibrinogen circulates in human plasma as a complex mixture of heterogeneous molecular variants. We measured strain-stiffening of recombinantly produced fibrinogen upon clotting. Factor XIII and molecular heterogeneity alter clot elasticity at the protofibril and fiber level. This highlights the hitherto unknown role of molecular composition in fibrin clot mechanics. Słowa kluczowe: blood coagulation, elasticity, fibrin, polymers, rheology, turbidimetry Afiliacje autorów:
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