| Partner: Armando Gagliardi Paolo |
Ostatnie publikacje
| 1. | Nałęcz-Jawecki P., Gagliardi Paolo A.♦, Kochańczyk M.R., Dessauges C.♦, Pertz O.♦, Lipniacki T., The MAPK/ERK channel capacity exceeds 6 bit/hour, PLOS COMPUTATIONAL BIOLOGY, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1011155, Vol.19, No.5, pp.e1011155-1-21, 2023 Streszczenie: Living cells utilize signaling pathways to sense, transduce, and process information. As the extracellular stimulation often has rich temporal characteristics which may govern dynamic cellular responses, it is important to quantify the rate of information flow through the signaling pathways. In this study, we used an epithelial cell line expressing a light-activatable FGF receptor and an ERK activity reporter to assess the ability of the MAPK/ERK pathway to transduce signal encoded in a sequence of pulses. By stimulating the cells with random light pulse trains, we demonstrated that the MAPK/ERK channel capacity is at least 6 bits per hour. The input reconstruction algorithm detects the light pulses with 1-min accuracy 5 min after their occurrence. The high information transmission rate may enable the pathway to coordinate multiple processes including cell movement and respond to rapidly varying stimuli such as chemoattracting gradients created by other cells. Afiliacje autorów:
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