| Partner: Du Jingtao |
Ostatnie publikacje
| 1. | Jingtao D.♦, Rybak D., Su Q.♦, Qiusheng W.♦, Qifan Y.♦, Jinlong G.♦, Yuhang W.♦, Nakielski P.♦, Xianfeng W.♦, Pierini F.♦, Jianyong Y.♦, Xiaoran L.♦, Bin D.♦, Sprayable Photothermal Fiber-Embedded Hydrogels to Engineer Microenvironment for Infected Wound Healing, Advanced Functional Materials, ISSN: 1616-301X, DOI: 10.1002/adfm.202501242, pp.2501242-1-14, 2025 Streszczenie: The treatment of infected irregular wounds remains one of the most significant challenges in clinical practice. Sprayable hydrogels have attracted considerable attention due to their favorable fitting with irregular wounds. However, the development of hydrogels with programmable anti-bacterial, anti-inflammatory, and regenerative properties to match the healing process still faces severe challenges. Herein, a versatile strategy is demonstrated to develop sprayable and photothermal fiber-embedded hydrogel dressings by incorporating the gold nanorods (AuNRs) and anti-inflammatory drug diclofenac sodium (DS)-loaded poly(lactic-co-glycolic acid) (PLGA) electrospun fibers into the stromal-cell-derived factor 1α (SDF-1α)-immobilized gelatin methacrylate hydrogel. Benefiting from the photothermal conversion property of AuNRs and the suitable glass transition temperature of PLGA short fibers, the hydrogels can not only realize a photothermal anti-bacterial effect, but also photo-triggered on-demand release of DS for anti-inflammatory activity. Furthermore, the sustained release of SDF-1α facilitates endogenous stem cell recruitment. The in vivo experiments demonstrate accelerated healing of infected wounds. The RNA-sequencing analysis reveals that the hydrogel is capable of suppressing the inflammatory response-related pathway. The photo-responsive fiber-embedded hydrogels offer a promising strategy for constructing a photo-triggered programmable therapeutic platform for regenerative medicine. Afiliacje autorów:
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| 2. | Rybak D., Jingtao D.♦, Nakielski P., Rinoldi C., Kosik-Kozioł A., Zakrzewska A., Haoyang W.♦, Jing L.♦, Li X.♦, Yunlong Y.♦, Ding B.♦, Pierini F., NIR-Light Activable 3D Printed Platform Nanoarchitectured with Electrospun Plasmonic Filaments for On Demand Treatment of Infected Wounds, ADVANCED HEALTHCARE MATERIALS, ISSN: 2192-2659, DOI: 10.1002/adhm.202404274, pp.2404274-1-17, 2024 Streszczenie: Bacterial infections can lead to severe complications that adversely affect wound healing. Thus, the development of effective wound dressings has become a major focus in the biomedical field, as current solutions remain insufficient for treating complex, particularly chronic wounds. Designing an optimal environment for healing and tissue regeneration is essential. This study aims to optimize a multi-functional 3D printed hydrogel for infected wounds. A dexamethasone (DMX)-loaded electrospun mat, incorporated with gold nanorods (AuNRs), is structured into short filaments (SFs). The SFs are 3D printed into gelatine methacrylate (GelMA) and sodium alginate (SA) scaffold. The photo-responsive AuNRs within SFs significantly enhanced DXM release when exposed to near-infrared (NIR) light. The material exhibits excellent photothermal properties, biocompatibility, and antibacterial activity under NIR irradiation, effectively eliminating Staphylococcus aureus and Escherichia coli in vitro. In vivo, material combined with NIR light treatment facilitate infectes wound healing, killing S. aureus bacteria, reduced inflammation, and induced vascularization. The final materials’ shape can be adjusted to the skin defect, release the anti-inflammatory DXM on-demand, provide antimicrobial protection, and accelerate the healing of chronic wounds. Afiliacje autorów:
|  | 140p. |