Tytuł projektu:
Wyznaczanie wskaźników reaktywnej odpowiedzi tętnicy promieniowej na przekrwienie w ocenie nadciśnienia tętniczego i choroby wieńcowej.


Umowa:
UMO-2017/25/B/ST7/01601

Czas realizacji:
2018-02-06 / 2021-02-05

Konsorcjum:
Jedyny wykonawca

Sponsor:
NCN

Typ:
OPUS

Konkurs:
13


Lista wykonawców:
1 prof. dr hab.Barbara Gambin
2 prof. dr hab. inż.Andrzej Nowicki
3 dr inż.Wojciech Secomski
4 dr inż.Zbigniew Trawiński
5 
kierownik

Streszczenie:
Endothelial monolayer plays important role in antiinflammatory and vasoregulatory functions. It has been shown in numerous studies the increase of vessel dilation after sudden increase of blood flow/ shear stress in the vessel after several minutes hyperemia, so after “mechanical” stimulation of the endothelium. Most of the reported research was conducted on the brachial artery.We are proposing measuring flow mediated dilation FMD and shear rate SR in the radial artery exhibiting higher FMD than the one in the brachial artery. In order to improve the measurements precision of vessel diameter and blood flow we have designed a high-frequency scanning system consisting of a 20 MHz linear array transducer combined with 20 MHz pulsed Doppler probe The degree of radial artery FMD an SR was evaluated in 14 healthy volunteers and 12 patients with chronic coronary artery disease CAD. Statistically significant differences in FMD and SR between the two groups were confirmed by a Wilcoxon-Mann-Whitney AUCs of ROC curves for FMD and FMD/SR were greater than 0.9. The results confirm the usefulness of the proposed measurements of radial artery FMD and SR in differentiation of normal subjects from those with chronic CAD.

Obszar, dziedziny i dyscypliny naukowej:
3.2.2:obszar nauk ścisłych, dziedzina nauk fizycznych, dyscyplina biofizyka
4.1.2:obszar nauk przyrodniczych, dziedzina nauk biologicznych, dyscyplina biofizyka
5.1.7:obszar nauk technicznych, dziedzina nauk technicznych, dyscyplina elektronika

Lista publikacji:
1.Nowicki A., Gambin B., Secomski W., Trawiński Z., Szubielski M., Tymkiewicz R., Olszewski R., Assessment of high frequency imaging and Doppler system for the measurements of the radial artery flow-mediated dilation, ARCHIVES OF ACOUSTICS, ISSN: 0137-5075, DOI: 10.24425/aoa.2019.129276, Vol.44, No.4, pp.637-644, 201970p.
2.Nowicki A., Trawiński Z., Gambin B., Secomski W., Szubielski M., Parol M., Olszewski R., 20-MHZ ultrasound for measurements offlow-mediated dilation and shear rate in the radialartery, ULTRASOUND IN MEDICINE AND BIOLOGY, ISSN: 0301-5629, DOI: 10.1016/j.ultrasmedbio.2018.02.011, Vol.44, No.6, pp.1187-1197, 201840p.